Computational identification of uncharacterized cruzain binding sites.

• Main Authors: Jacob D Durrant (Author), Henrik Keränen (Author), Benjamin A Wilson (Author), J Andrew McCammon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, claims 50,000 lives annually and is the leading cause of infectious myocarditis in the world. As current antichagastic therapies like nifurtimox and benznidazole are highly toxic, ineffective at parasite eradication, and subject t...