Designing a bis-azide photoaffinity probe in labeling influenza nucleoprotein trimer to give an insight into the binding mode

• Główni autorzy: Pin-Hsuan Chiu (Autor), Wei Huang (Autor), Hua-Ting Hsu (Autor), Wen-Feng Huang (Autor), Ying-Ta Wu (Autor), Ting-Jen Rachel Cheng (Autor), Jim-Min Fang (Autor)
• Format: Książka
• Wydane: Elsevier, 2022-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Targeting the highly conserved E330 ... R416 salt bridge involved in nucleoprotein (NP) trimerization is considered a favorable approach to address the problem of drug resistance in influenza therapy. A photoaffinity probe (1) containing aryl and alkyl azide moieties was synthesized and applied to i...