Designing a bis-azide photoaffinity probe in labeling influenza nucleoprotein trimer to give an insight into the binding mode

• Main Authors: Pin-Hsuan Chiu (Author), Wei Huang (Author), Hua-Ting Hsu (Author), Wen-Feng Huang (Author), Ying-Ta Wu (Author), Ting-Jen Rachel Cheng (Author), Jim-Min Fang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting the highly conserved E330 ... R416 salt bridge involved in nucleoprotein (NP) trimerization is considered a favorable approach to address the problem of drug resistance in influenza therapy. A photoaffinity probe (1) containing aryl and alkyl azide moieties was synthesized and applied to i...