Designing a bis-azide photoaffinity probe in labeling influenza nucleoprotein trimer to give an insight into the binding mode

• Asıl Yazarlar: Pin-Hsuan Chiu (Yazar), Wei Huang (Yazar), Hua-Ting Hsu (Yazar), Wen-Feng Huang (Yazar), Ying-Ta Wu (Yazar), Ting-Jen Rachel Cheng (Yazar), Jim-Min Fang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2022-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Targeting the highly conserved E330 ... R416 salt bridge involved in nucleoprotein (NP) trimerization is considered a favorable approach to address the problem of drug resistance in influenza therapy. A photoaffinity probe (1) containing aryl and alkyl azide moieties was synthesized and applied to i...