The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients

• 主要な著者: Hadeel Obiedat (著者), Nasr Alrabadi (著者), Eyad Sultan (著者), Marwa Al Shatti (著者), Malek Zihlif (著者)
• フォーマット: 図書
• 出版事項: BMC, 2018-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background Cisplatin is one of the major drugs that used in the treatment of osteosarcoma. Cisplatin exerts its function by making cisplatin-DNA adducts culminating in cellular death. These adducts found to be repaired by nucleotide excision repair (NER) pathway. This study aimed to evaluat...