The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients

• Main Authors: Hadeel Obiedat (Author), Nasr Alrabadi (Author), Eyad Sultan (Author), Marwa Al Shatti (Author), Malek Zihlif (Author)
• Format: Bog
• Udgivet: BMC, 2018-07-01T00:00:00Z.
• Fag: article
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Abstract Background Cisplatin is one of the major drugs that used in the treatment of osteosarcoma. Cisplatin exerts its function by making cisplatin-DNA adducts culminating in cellular death. These adducts found to be repaired by nucleotide excision repair (NER) pathway. This study aimed to evaluat...