Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production.

• Main Authors: Bilin Dong (Author), Zhongsheng Tong (Author), Ruoyu Li (Author), Sharon C-A Chen (Author), Weihuang Liu (Author), Wei Liu (Author), Yao Chen (Author), Xu Zhang (Author), Yiqun Duan (Author), Dongsheng Li (Author), Liuqing Chen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fonsecaea pedrosoi (F. pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Experimental studies in murine models have shown that the...