Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

• Main Authors: Man Xiao (Author), Jing Cai (Author), Liqiong Cai (Author), Jinghui Jia (Author), Lisha Xie (Author), Ying Zhu (Author), Bangxing Huang (Author), Dongdong Jin (Author), Zehua Wang (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Resistance to platinum-based chemotherapy remains a great challenge for ovarian cancer treatment. The human let-7 family contains 13 members located on nine different chromosomes, and most members have been implicated in the modulation of drug sensitivity in cancers. Our previous...