Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations: A case report

• Glavni autori: Camilo Scherkl (Autor), Andreas D. Meid (Autor), Sven E. Cuntz (Autor), Laura Classen (Autor), Johanna Weiss (Autor), David Czock (Autor), Walter E. Haefeli (Autor)
• Format: Knjiga
• Izdano: Wiley, 2024-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Individual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food. Therapeutic drug monitoring is therefore recommended, especially at treatment start or in circums...