The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity

• Main Authors: Karen M Page (Author), Vadim M Gumerov (Author), Shehrazade Dahimene (Author), Igor B Zhulin (Author), Annette C Dolphin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTIn this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are present in all α2δ proteins. We have also included new da...