The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity

• Ngā kaituhi matua: Karen M Page (Author), Vadim M Gumerov (Author), Shehrazade Dahimene (Author), Igor B Zhulin (Author), Annette C Dolphin (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

ABSTRACTIn this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are present in all α2δ proteins. We have also included new da...