5-aza-2'-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas

• Main Authors: María Cristina Carbajo-García (Author), Ana Corachán (Author), Marina Segura-Benitez (Author), Javier Monleón (Author), Julia Escrig (Author), Amparo Faus (Author), Antonio Pellicer (Author), Irene Cervelló (Author), Hortensia Ferrero (Author)
• Format: Book
• Published: BMC, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2'-deoxycytidine (5-aza-CdR), have been suggested to treat tumors in which DNA methyla...