Increased Excretion of Urinary 20-HETE in Rats With Cyclosporine-Induced Nephrotoxicity

• Prif Awduron: Takayuki Seki (Awdur), Tsuyoshi Ishimoto (Awdur), Takanobu Sakurai (Awdur), Yoshiko Yasuda (Awdur), Kazuo Taniguchi (Awdur), Mariko Doi (Awdur), Mariko Sato (Awdur), Richard J. Roman (Awdur), Noriyuki Miyata (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2005-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The present study examined the contribution of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in cyclosporine A (CsA)-induced renal nephrotoxicity. Treatment of rats with CsA (50 mg/kg) for 9 days induced renal damage as indicated by marked increase in urine flow (from 9.0 ± 0.3 ml/day to 46.6...