Increased Excretion of Urinary 20-HETE in Rats With Cyclosporine-Induced Nephrotoxicity

• Main Authors: Takayuki Seki (Author), Tsuyoshi Ishimoto (Author), Takanobu Sakurai (Author), Yoshiko Yasuda (Author), Kazuo Taniguchi (Author), Mariko Doi (Author), Mariko Sato (Author), Richard J. Roman (Author), Noriyuki Miyata (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study examined the contribution of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in cyclosporine A (CsA)-induced renal nephrotoxicity. Treatment of rats with CsA (50 mg/kg) for 9 days induced renal damage as indicated by marked increase in urine flow (from 9.0 ± 0.3 ml/day to 46.6...