Increased Excretion of Urinary 20-HETE in Rats With Cyclosporine-Induced Nephrotoxicity

• Główni autorzy: Takayuki Seki (Autor), Tsuyoshi Ishimoto (Autor), Takanobu Sakurai (Autor), Yoshiko Yasuda (Autor), Kazuo Taniguchi (Autor), Mariko Doi (Autor), Mariko Sato (Autor), Richard J. Roman (Autor), Noriyuki Miyata (Autor)
• Format: Książka
• Wydane: Elsevier, 2005-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The present study examined the contribution of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in cyclosporine A (CsA)-induced renal nephrotoxicity. Treatment of rats with CsA (50 mg/kg) for 9 days induced renal damage as indicated by marked increase in urine flow (from 9.0 ± 0.3 ml/day to 46.6...