Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme

• Main Authors: Liangfang Shen (Author), Qin Zhou (Author), Ying Wang (Author), Weihua Liao (Author), Yan Chen (Author), Zhijie Xu (Author), Lifang Yang (Author), Lun-Quan Sun (Author)
• Format: Book
• Published: BMC, 2013-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Antiangiogenesis is a promising antitumor strategy that inhibits tumor vascular formation to suppress tumor growth. DNAzymes are synthetic single-strand deoxyribonucleic acid (DNA) molecules that can cleave ribonucleic acids (RNAs). Here, we conducted a comprehensive in vitroselection of ac...