Toll-Like Receptor 4 Mediated Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation in Vascular Smooth Muscle Cells via Src and Sirt1/3 Pathway

• Main Authors: Zhongli Chen (Author), Qiqi Xue (Author), Lijuan Cao (Author), Yanpin Wang (Author), Yuanyuan Chen (Author), Xiaojie Zhang (Author), Fan Xiao (Author), Ying Yang (Author), Melvin R. Hayden (Author), Yan Liu (Author), Ke Yang (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidized low-density lipoprotein (oxLDL) induced a foam-cell-like phenotype of the vascular smooth muscle cells (VSMCs), leading to the inflammatory responses incorporating Toll-like receptor- (Tlr-) mediated cellular alterations. However, the role of Tlr4 in foam cell formation and underlying molec...