Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni.

• Main Authors: Sandra D Melman (Author), Michelle L Steinauer (Author), Charles Cunningham (Author), Laura S Kubatko (Author), Ibrahim N Mwangi (Author), Nirvana Barker Wynn (Author), Martin W Mutuku (Author), Diana M S Karanja (Author), Daniel G Colley (Author), Carla L Black (Author), William Evan Secor (Author), Gerald M Mkoji (Author), Eric S Loker (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The near exclusive use of praziquantel (PZQ) for treatment of human schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes.We measured susceptibility to PZQ of isolates of Schistosoma mansoni obtained from patients from Kisumu, Kenya continuously exposed to i...