Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate

• Main Authors: Chenxin Duan (Author), Wenwen Liu (Author), Yunwen Tao (Author), Feifei Liang (Author), Yanming Chen (Author), Xinyi Xiao (Author), Guisen Zhang (Author), Yin Chen (Author), Chao Hao (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions. In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared by ev...