Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection

• Main Authors: Manuel Salzmann (Author), Patrick Haider (Author), Christoph Kaun (Author), Mira Brekalo (Author), Boris Hartmann (Author), Theresia Lengheimer (Author), Rebecca Pichler (Author), Thomas Filip (Author), Sophia Derdak (Author), Bruno Podesser (Author), Christian Hengstenberg (Author), Walter S. Speidl (Author), Johann Wojta (Author), Roberto Plasenzotti (Author), Philipp J. Hohensinner (Author)
• Format: Book
• Published: Karger Publishers, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes responsible for these immunological benefits. We used a murine co...