Suppression of hypoxia and inflammatory pathways by Phyllanthus niruri extract inhibits angiogenesis in DMBA-induced breast cancer mice

• Main Authors: Abu Hanifah Ramadhani (Author), Ahmad Hafidul Ahkam (Author), Aditya Ragil Suharto (Author), Yoga Dwi Jatmiko (Author), Hideo Tsuboi (Author), Muhaimin Rifa'i (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Angiogenesis has been one of the hallmarks of cancer. In recent years, Phyllanthus niruri extract (PNE) was reported to inhibit angiogenesis by decreasing the levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1a (HIF-1a) in breast cancer. Howeve...