Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages

• Main Authors: Stephanie B. Wall (Author), Rui Li (Author), Brittany Butler (Author), Ashley R. Burg (Author), Hubert M. Tse (Author), Jennifer L. Larson-Casey (Author), A. Brent Carter (Author), Clyde J. Wright (Author), Lynette K. Rogers (Author), Trent E. Tipple (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Alveolar macrophages (AMs) are resident inflammatory cells in the lung that serve as early sentinels of infection or injury. We have identified thioredoxin reductase 1 inhibition by gold compounds increases activation of nuclear factor erythroid 2-related factor 2 (NRF2)-dependent pathwa...