Prevalence and clinical phenotype of the triplicated α-globin genes and its ethnic and geographical distribution in Guizhou of China

• Hauptverfasser: Xi Luo (Verfasst von), Xiang-mei Zhang (Verfasst von), Liu-song Wu (Verfasst von), Jindong Chen (Verfasst von), Yan Chen (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2021-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background α-thalassemia is relatively endemic in Guizhou province of southwestern China. To predict the clinical manifestations of α-globin gene aberration for genetic counseling, we examined the prevalence of the α-globin triplication and the genotype-phenotype correlation in this subpopu...