Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

• Main Authors: Taylor Landry (Author), Peixin Li (Author), Daniel Shookster (Author), Zhiying Jiang (Author), Hongli Li (Author), Brenton Thomas Laing (Author), Wyatt Bunner (Author), Theodore Langton (Author), Qingchun Tong (Author), Hu Huang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho in the arcuate nucleus of the hypothalamus (A...