Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study

• Main Authors: Talib Hussain (Author), Ahmed Alafnan (Author), Ibrahim Abdullah Almazni (Author), Nawal Helmi (Author), Afrasim Moin (Author), Hanadi M. Baeissa (Author), Amir Mahgoub Awadelkareem (Author), AbdElmoneim O. Elkhalifa (Author), Tahani Bakhsh (Author), Abdulrahman Alzahrani (Author), Rashed Mohammed Alghamdi (Author), Mohammad Khalid (Author), Rohit Kumar Tiwari (Author), Syed Mohd Danish Rizvi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with the initiation and subsequent progression of prostate carcinomas. The present report elucidated the anti-cancerous attributes of an anthraquinone, aloe-emodin (AE), against androgen-ind...