Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

• Main Authors: Stephen R Doyle (Author), Catherine Bourguinat (Author), Hugues C Nana-Djeunga (Author), Jonas A Kengne-Ouafo (Author), Sébastien D S Pion (Author), Jean Bopda (Author), Joseph Kamgno (Author), Samuel Wanji (Author), Hua Che (Author), Annette C Kuesel (Author), Martin Walker (Author), Maria-Gloria Basáñez (Author), Daniel A Boakye (Author), Mike Y Osei-Atweneboana (Author), Michel Boussinesq (Author), Roger K Prichard (Author), Warwick N Grant (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvulus populati...