Riluzole attenuates acute neural injury and reactive gliosis, hippocampal-dependent cognitive impairments and spontaneous recurrent generalized seizures in a rat model of temporal lobe epilepsy

• 主要な著者: Thomas Kyllo (著者), Dominic Allocco (著者), Laine Vande Hei (著者), Heike Wulff (著者), Jeffrey D. Erickson (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

BackgroundRiluzole exhibits neuroprotective and therapeutic effects in several neurological disease models associated with excessive synaptic glutamate (Glu) release. We recently showed riluzole prevents acute excitotoxic hippocampal neural injury at 3 days in the kainic acid (KA) model of temporal...