Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2

• Main Authors: Xiaolin Li (Author), Tosca Holtrop (Author), Fleur A.C. Jansen (Author), Brennan Olson (Author), Pete Levasseur (Author), Xinxia Zhu (Author), Mieke Poland (Author), Winni Schalwijk (Author), Renger F. Witkamp (Author), Daniel L. Marks (Author), Klaske vanNorren (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia‐anorexia syndrome is a complex metabolic condition characterized by skeletal muscle wasting, reduced food intake and prominent involvement of systemic and central inflammation. Here, the gut barrier function was investigated in pancreatic cancer‐induced cachexia mouse mo...