A Risk Scoring Model for High-Dose Methotrexate-Induced Liver Injury in Children With Acute Lymphoblastic Leukemia Based on Gene Polymorphism Study

• Main Authors: Xia He (Author), Pingli Yao (Author), Mengting Li (Author), Hong Liang (Author), Yilong Liu (Author), Shan Du (Author), Min Zhang (Author), Wenzhuo Sun (Author), Zeyuan Wang (Author), Xin Hao (Author), Ze Yu (Author), Fei Gao (Author), Xinxia Liu (Author), Rongsheng Tong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A study on 70 acute lymphoblastic leukemia (ALL) children (age ≤16 years) treated with high-dose methotrexate (HD-MTX) in Sichuan Provincial People's Hospital was conducted. The aim of the study was to establish a risk-scoring model to predict HD-MTX-induced liver injury, considering gene polym...