ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch

• Main Authors: Liqing Jiang (Author), Linhe Lu (Author), Chao Xue (Author), He Sun (Author), Kai Ren (Author), Liyun Zhang (Author), Hanzhao Zhu (Author), Bin Zhang (Author), Xiaoya Wang (Author), Xinan Qiao (Author), Xiangyan Peng (Author), Jincheng Liu (Author), Weixun Duan (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Thoracic aortic dissection (TAD) is an irreversible cardiovascular disorder with high mortality and morbidity. However, the molecular mechanisms remain elusive. Thus, identifying an effective therapeutic target to prevent TAD is especially critical. The purpose of this study is t...