A Toll‐like receptor‐4/NLRP3 inflammasome pathway promotes inflammation in skeletal muscle of chronic kidney disease patients

• Main Authors: Daniela Verzola (Author), Pasquale Esposito (Author), Samantha Milanesi (Author), Michela Saio (Author), Daniela Picciotto (Author), Marco Frascio (Author), Alessandro Laudon (Author), Giacomo Garibotto (Author), Giuliano Brunori (Author), Francesca Viazzi (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background An emerging hypothesis is that the activation of innate immunity in the muscle of patients with chronic kidney disease (CKD) is implicated in the development and progression of wasting and cachexia. We previously observed that Toll‐like receptor‐4 (TLR4) and its downward NF‐κB‐de...