Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer

• Main Authors: Zheng Cai (Author), Xiaolu Lei (Author), Zhufen Lin (Author), Jie Zhao (Author), Feizhen Wu (Author), Zhaoxiang Yang (Author), Junxue Pu (Author), Zhongqiu Liu (Author)
• Format: Book
• Published: Elsevier, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Borneol is a traditional Chinese medicine that can promote drug absorption from the gastrointestinal tract and distribution to the brain. However, stomach irritation may occur when high doses of borneol are used. In the present work, gastrodin, the main bioactive ingredient of the traditional Chines...