Unraveling the genetic diversity and phylogeny of Leishmania RNA virus 1 strains of infected Leishmania isolates circulating in French Guiana.

• Main Authors: Sourakhata Tirera (Author), Marine Ginouves (Author), Damien Donato (Author), Ignacio S Caballero (Author), Christiane Bouchier (Author), Anne Lavergne (Author), Eliane Bourreau (Author), Emilie Mosnier (Author), Vincent Vantilcke (Author), Pierre Couppié (Author), Ghislaine Prevot (Author), Vincent Lacoste (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania RNA virus type 1 (LRV1) is an endosymbiont of some Leishmania (Vianna) species in South America. Presence of LRV1 in parasites exacerbates disease severity in animal models and humans, related to a disproportioned innate immune response, and is correlated with drug treatment failures in h...