Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

• Main Authors: Daniel García-Rincón (Author), Javier Díaz-Alonso (Author), Juan Paraíso-Luna (Author), Zaira Ortega (Author), José Aguareles (Author), Adán de Salas-Quiroga (Author), Cristina Jou (Author), Inmaculada de Prada (Author), Verónica Martínez-Cerdeño (Author), Eleonora Aronica (Author), Manuel Guzmán (Author), María Ángeles Pérez-Jiménez (Author), Ismael Galve-Roperh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and megalencephaly. These MCDs represent a frequent cause...