The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood-Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood-Brain Barrier In Vitro and In Vivo

• Main Authors: Emma Lisa Al Humaidan (Author), Sidse Lund Pedersen (Author), Annette Burkhart (Author), Charlotte Laurfelt Munch Rasmussen (Author), Torben Moos (Author), Peter Fuchs (Author), Eduardo Filipe Alves Fernandes (Author), Burak Ozgür (Author), Kristian Strømgaard (Author), Anders Bach (Author), Birger Brodin (Author), Mie Kristensen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of the interaction between the scaffolding protein PSD-95 and the NMDA receptor has been shown to obstruct ischemic stroke-triggered excitotoxic reactions, leading to neuronal death. The peptides NR2B9c and N-dimer are inhibitors of this interaction. Delivery of the peptides to the brain...