Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

The drug-drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs). Drugs that affect gastric emptying, including dulaglutide, also affect atorvastatin pharmacokinetics (PK). Atorvastatin is a car...

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Main Authors: Bridget L. Morse (Author), Jeffrey J. Alberts (Author), Maria M. Posada (Author), Jessica Rehmel (Author), Anil Kolur (Author), Lai San Tham (Author), Corina Loghin (Author), Kathleen M. Hillgren (Author), Stephen D. Hall (Author), Gemma L. Dickinson (Author)
Format: Book
Published: Wiley, 2019-09-01T00:00:00Z.
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