Clinical Pharmacology of Paracetamol in Neonates: A Review

• المؤلفون الرئيسيون: Gian Maria Pacifici, MD, PhD (مؤلف), Karel Allegaert, MD, PhD (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2015-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Paracetamol is commonly used to control mild-to-moderate pain or to reduce opioid exposure as part of multimodal analgesia, and is the only compound recommended to treat fever in neonates. Paracetamol clearance is lower in neonates than in children and adults. After metabolic conversion, paracetamol...