Xiaoyaosan Ameliorates Chronic Restraint Stress-Induced Depression-Like Phenotype by Suppressing A2AR Signaling in the Rat Striatum

• Main Authors: Xiaoxu Zhu (Author), Qingyu Ma (Author), Furong Yang (Author), Xiaojuan Li (Author), Yueyun Liu (Author), Jianbei Chen (Author), Lan Li (Author), Man Chen (Author), Xiaojuan Zou (Author), Li Yan (Author), Jiaxu Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is a common mental disorder characterized by pessimism and world-weariness. In our previous study, we found that Xiaoyaosan (XYS) could have antidepressive effects, however the underlying mechanisms remain unclear. Several studies have shown that adenosine A (2 A) receptor (A2AR) in the b...