Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

• Autori principali: Águeda González-Rodríguez (Autore), M. Pilar Valdecantos (Autore), Patricia Rada (Autore), Annalisa Addante (Autore), Inés Barahona (Autore), Esther Rey (Autore), Virginia Pardo (Autore), Laura Ruiz (Autore), Laura M. Laiglesia (Autore), María J. Moreno-Aliaga (Autore), Carmelo García-Monzón (Autore), Aránzazu Sánchez (Autore), Ángela M. Valverde (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2018-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. Protein tyrosine phosphatase 1B (PTP1B), a negative modulator of insulin and cytokine signaling, is a therapeutic target for type 2 diabetes and obesity. We investigated the impact of...