The controversy of klotho as a potential biomarker in chronic kidney disease

• Main Authors: Li-Xia Yu (Author), Sha-Sha Li (Author), Min-Yue Sha (Author), Jia-Wei Kong (Author), Jian-Ming Ye (Author), Qi-Feng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney. Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease (CKD) and continues as CKD progresses. Klotho deficiency is associated with poor clinical outcomes and CKD mineral bone...