Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: preliminary findings

• Main Authors: Muriah Dawn Wheelock (Author), Meredith A Reid (Author), Harrison eTo (Author), David eWhite (Author), Karen L Cropsey (Author), Adrienne Carol Lahti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rationale: Varenicline, the most effective single agent for smoking cessation, is a partial agonist at α4β2 nicotinic acetylcholine receptors. Increasing evidence implicates glutamate in the pathophysiology of addiction and one of the benefits of treatment for smoking cessation is the ability to reg...