Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex

• Main Authors: Maxim A.X. Tollenaere (Author), Christina Mølck (Author), Ian Henderson (Author), Scott Pollack (Author), Philip Addis (Author), Helle Heibroch Petersen (Author), Hanne Norsgaard (Author)
• 格式: 图书
• 出版: Elsevier, 2023-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Tralokinumab, a fully human mAb specifically targeting the IL-13 cytokine, has demonstrated clinical efficacy and safety in patients with moderate-to-severe atopic dermatitis. Tralokinumab binds IL-13 with high affinity, which prevents the interaction of IL-13 with IL-13Rα1 and subsequent signaling....