Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury

• Main Authors: Fei Yao (Author), Yang Luo (Author), Yan-Chang Liu (Author), Yi-Hao Chen (Author), Yi-Teng Li (Author), Xu-Yang Hu (Author), Xing-Yu You (Author), Shui-Sheng Yu (Author), Zi-Yu Li (Author), Lei Chen (Author), Da-Sheng Tian (Author), Mei-Ge Zheng (Author), Li Cheng (Author), Jue-Hua Jing (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in permanent functional recovery failure. Pericytes were shown to be the ma...