From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and further enhanced by chemotherapy as a mechanism of dru...

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Main Authors: Andrea Astolfi (Author), Francesca Milano (Author), Deborah Palazzotti (Author), Jose Brea (Author), Maria Chiara Pismataro (Author), Mariangela Morlando (Author), Oriana Tabarrini (Author), Maria Isabel Loza (Author), Serena Massari (Author), Maria Paola Martelli (Author), Maria Letizia Barreca (Author)
Format: Book
Published: MDPI AG, 2022-10-01T00:00:00Z.
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3rd Floor Main Library

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