Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells

• Main Authors: Toshiharu Onodera (Author), Dae-Seok Kim (Author), Risheng Ye (Author), May-Yun Wang (Author), Shiuhwei Chen (Author), Bianca C. Field (Author), Leon Straub (Author), Xue-Nan Sun (Author), Chao Li (Author), Charlotte Lee (Author), Megan Paredes (Author), Clair Crewe (Author), Shangang Zhao (Author), Christine M. Kusminski (Author), Ruth Gordillo (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The disease progression of the metabolic syndrome is associated with prolonged hyperlipidemia and insulin resistance, eventually giving rise to impaired insulin secretion, often concomitant with hypoadiponectinemia. As an adipose tissue derived hormone, adiponectin is beneficial for insulin secretio...