A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever.

• Main Authors: Robert T Cartee (Author), Ann Thanawastien (Author), Thomas J Griffin Iv (Author), John J Mekalanos (Author), Stephan Bart (Author), Kevin P Killeen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited, short-term protection and are not approved for youn...