DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy

• Main Authors: Hsiang-I Tsai (Author), Lijuan Jiang (Author), Xiaowei Zeng (Author), Hongbo Chen (Author), Zihuang Li (Author), Wei Cheng (Author), Jinxie Zhang (Author), Jie Pan (Author), Dong Wan (Author), Li Gao (Author), Zhenhua Xie (Author), Laiqiang Huang (Author), Lin Mei (Author), Gan Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoam...