A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis

• Main Authors: Nobuko Matsumura (Author), Chisato Kinoshita (Author), Wattanaporn Bhadhprasit (Author), Toshio Nakaki (Author), Koji Aoyama (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purine derivatives such as caffeine and uric acid have neuroprotective activities and are negatively correlated with the incidence of both Alzheimer's disease and Parkinson's disease. We have reported that an increment of intracellular glutathione (GSH) via cysteine uptake in neuronal cell...