Cleavable PEGylation: a strategy for overcoming the "PEG dilemma" in efficient drug delivery

• Ngā kaituhi matua: Yan Fang (Author), Jianxiu Xue (Author), Shan Gao (Author), Anqi Lu (Author), Dongjuan Yang (Author), Hong Jiang (Author), Yang He (Author), Kai Shi (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2017-11-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and...