Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host

• Main Authors: Ute Jungwirth (Author), Antoinette van Weverwijk (Author), Miriam J. Melake (Author), Ann F. Chambers (Author), Qiong Gao (Author), Marc Fivaz (Author), Clare M. Isacke (Author)
• Format: Book
• Published: The Company of Biologists, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Studying the complex mechanisms underlying breast cancer metastasis and therapy response necessitates relevant in vivo models, particularly syngeneic models with an intact immune system. Two syngeneic spontaneously metastatic sublines, D2A1-m1 and D2A1-m2, were generated from the poorly metastasisin...