Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS

• Main Authors: Adila El-Obeid (Author), Yahya Maashi (Author), Rehab AlRoshody (Author), Ghada Alatar (Author), Modhi Aljudayi (Author), Hamad Al-Eidi (Author), Nouf AlGaith (Author), Altaf Husain Khan (Author), Adil Hassib (Author), Sabine Matou-Nasri (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract We reported a gastric anti-ulcerogenic effect of the Nigella sativa (L.)-derived herbal melanin (HM) using rat models. However, the molecular mechanisms underlying this HM gastroprotective effect remain unknown. Cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E2 (PGE2) and toll-like recept...