Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS

• প্রধান লেখক: Adila El-Obeid (লেখক), Yahya Maashi (লেখক), Rehab AlRoshody (লেখক), Ghada Alatar (লেখক), Modhi Aljudayi (লেখক), Hamad Al-Eidi (লেখক), Nouf AlGaith (লেখক), Altaf Husain Khan (লেখক), Adil Hassib (লেখক), Sabine Matou-Nasri (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2023-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract We reported a gastric anti-ulcerogenic effect of the Nigella sativa (L.)-derived herbal melanin (HM) using rat models. However, the molecular mechanisms underlying this HM gastroprotective effect remain unknown. Cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E2 (PGE2) and toll-like recept...