S1, a Novel Pan-BH3 Mimetic, Induces Apoptosis in Mcl-1-Overexpressing Cells Through Bak

Mcl-1, an anti-apoptotic Bcl-2 homolog that has a structurally divergent BH3-binding pocket, non-redundant action model, and unique characteristic of short life confers complete resistance to the BH3 mimetic ABT-737. Herein, we used S1, previously identified as a Mcl-1/Bcl-2 dual inhibitor and a pur...

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Main Authors: Ting Song (Author), Xilong Chang (Author), Zhichao Zhang (Author), Yubo Liu (Author), Xiaoyun Shen (Author)
Format: Book
Published: Elsevier, 2012-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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