S1, a Novel Pan-BH3 Mimetic, Induces Apoptosis in Mcl-1-Overexpressing Cells Through Bak
Mcl-1, an anti-apoptotic Bcl-2 homolog that has a structurally divergent BH3-binding pocket, non-redundant action model, and unique characteristic of short life confers complete resistance to the BH3 mimetic ABT-737. Herein, we used S1, previously identified as a Mcl-1/Bcl-2 dual inhibitor and a pur...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2012-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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