Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate.

Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate.

We recently described a new, live-attenuated vaccine candidate for chikungunya (CHIK) fever, CHIKV/IRES. This vaccine was shown to be well attenuated, immunogenic and efficacious in protecting against CHIK virus (CHIKV) challenge of mice and nonhuman primates. To further evaluate its preclinical saf...

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Main Authors: Kenneth S Plante (Author), Shannan L Rossi (Author), Nicholas A Bergren (Author), Robert L Seymour (Author), Scott C Weaver (Author)
Format: Book
Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
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