Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways.

• Main Authors: Jacob M Wozniak (Author), Tatiana Araújo Silva (Author), Diane Thomas (Author), Jair L Siqueira-Neto (Author), James H McKerrow (Author), David J Gonzalez (Author), Claudia M Calvet (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in life. Cardiomyopathies in particular are the most...