The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling

• Main Authors: Annamaria Fidilio (Author), Margherita Grasso (Author), Rita Turnaturi (Author), Giuseppe Caruso (Author), Federica Maria Spitale (Author), Nunzio Vicario (Author), Rosalba Parenti (Author), Salvatore Spoto (Author), Nicolò Musso (Author), Agostino Marrazzo (Author), Santina Chiechio (Author), Filippo Caraci (Author), Lorella Pasquinucci (Author), Carmela Parenti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyperalgesia and allodynia linked to an aberrant processing of pain transmission and to neuroinflammation. Transforming growth factor-β1 (TGF-β1) is an anti-inflammatory cytokine, which protects against ne...